Breast cancer seizures

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Metastatic breast canceralso referred to as metastasesadvanced breast cancer, secondary tumours, secondaries or stage 4 breast cancer, is a stage of breast cancer where the disease has spread to distant sites beyond the axillary lymph nodes. There is no cure for metastatic breast cancer. There is no stage after IV.

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A seizure is a sudden attack caused by problems with the electrical messages in your brain. Some chemotherapy may increase your risk of having a seizure. However, this risk is very small in most cases.

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Metastatic breast cancer is also classified as Stage 4 breast cancer. The cancer has spread to other parts of the body. This usually includes the lungs, liver, bones or brain.

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Skip to Content. In addition to physical changes, people with a brain tumor or cancer that has spread to the brain can experience changes in their mood, personality, and thinking. As a result, caregivers often have a variety of responsibilities that can become overwhelming. Planning for this role will help you provide quality care while also taking care of your health and well-being.

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Sometimes, brain metastases are found when breast cancer is first diagnosed, but the majority of the time, brain metastases occur as a distant recurrence of an early-stage breast cancer that was treated in the past. What symptoms may occur, and what treatment options are available if your breast cancer spreads to your brain? Overall, brain metastases occur in 15 to 24 percent of women with metastatic breast cancer.

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While the evidence base for the use of antiepileptic drugs for cancer-associated seizures is scant, a key consideration is the potentially harmful interaction between antiepileptics, corticosteroids, and many chemotherapy agents. Epileptic seizures—potentially life-threatening, transient disruptions of motor control and neurocognitive function caused by aberrant neuronal activity synaptic firing patterns in the brain—are common among patients with cancer, particularly those with primary or metastatic solid tumors in the brain or subarachnoid space leptomeningeal disease. The underlying etiology of seizures in patients with cancer can be complex, involving anatomic and metabolic disruptions caused by brain tumors themselves, tumor- or medication-related stroke or opportunistic infection, chemotherapy, or neuroradiotherapy.

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Researchers from Northwestern University, Evanston, Illinois, have discovered a new factor in the escalation of seizures: the synthesis, or generation, of estrogens in the brain. Their study in rats, published in the journal eLifealso suggests that using a drug that inhibits estrogen synthesis, called an aromatase inhibitor, may be an effective approach to controlling seizures. Seizures occur when connected groups of cells in the brain become over-active and fire together. Current treatments work by dampening brain activity generally, which is often effective in controlling seizures, but can also lead to negative side-effects such as drowsiness, dizziness, or difficulty concentrating.

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A seizure is the uncontrolled movement of muscles. Seizures usually last less than 5 minutes. They are followed by sleepiness and confusion that can last for several hours.

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There are few data available on the causes and mechanistic basis, outcome and treatment of seizures and epilepsy in people with systemic cancer. Seizures and epilepsy in people with cancers other than primary brain tumours are reviewed here. Articles published in English, which discussed the neurological manifestations and complications of cancer and its treatment, were searched and information on the frequency, aetiology, and course of seizures and epilepsy was extracted. The frequency, aetiology and outcome of seizure disorders in patients with cancer differ from those in the general population.


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