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Epigenetic changes in the nervous system are emerging as a critical component of enduring effects induced by early life experience, hormonal exposure, trauma and injury, or learning and memory. Sex differences in the brain are largely determined by steroid hormone exposure during a perinatal sensitive period that alters subsequent hormonal and nonhormonal responses throughout the lifespan. Steroid receptors are members of a nuclear receptor transcription factor superfamily and recruit multiple proteins that possess enzymatic activity relevant to epigenetic changes such as acetylation and methylation.
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Celebrity BB star Verne Troyer was a tight-fisted control freak obsessed with sex and spending his days reading about himself on the web, according to his ex-lover. She ran his errands and read out his bizarre fan mail while he spent all day googling his own name. She says Verne - then aged 40 - reduced her to tears through his mean behaviour and dangerously heavy drinking.
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Sex-related differences have been noted in cardiovascular anatomy, pathophysiology, and treatment responses, yet we continued to drive evaluation of vascular device development in animal models without consideration of animal sex. We aimed to understand sex-related differences in the vascular responses to stent implantation by analyzing the pooled data of endovascular interventions in Yucatan mini-swine 87 female, 77 male. Histomorphological parameters were evaluated from vascular specimens at 3— days after stent implantation and evaluated values were compared between female and male groups. While neointima formation at all times after implantation was invariant to sex, statistically significant differences between female and male groups were observed in injury, inflammation, adventitial fibrosis, and neointimal fibrin deposition.